Objective: To determine the socio-familial factors associated with quality of life within the family in children of schools in Piura, Peru. Subjects and Method: A cross-sectional study in a convenience sample of children between 3 to 6 years in schools in the city of Piura, Peru. The quality of life was measured by the HOME test, with data adjusted to the Machover and Koppitz test, and were also associated with other social and family variables. P values were obtained by generalised linear models, adjusting for the residence of each subject. Results: Of the 431 respondents, 64% (275) were male. The median age was 4 years old. A poor quality of life was observed in 50% of children. Traits of violence (p < .001) and aggression (p < .001) were associated to higher frequencies of poor quality of life, adjusted for shyness, dependence, and immaturity. The perception of parent’s love (p = .005), living with both parents (p < .001), playing with someone at home (p = .036), the person with whom plays most is the mother (p = .003) or both parents (p = .004) were associated with the quality of life in the survey. Conclusions: A large percentage of children who had a poor quality of life was found. The social and family protective factors were to live with both parents, and the demonstration of affection between both parents and play with both.