Title
Liver transplantation for autoimmune hepatitis in Peru: Outcomes and recurrence
Date Issued
01 January 2012
Access level
open access
Resource Type
research article
Publisher(s)
Fundación Clínica Médica Sur
Abstract
Liver transplantation is the only therapy for end-stage liver disease. Cirrhosis secondary to autoimmune hepatitis (AIH) is an indication in 4-6% of adult transplants. Aims. To describe the outcomes and recurrence of AIH in liver transplant patients. Material and methods. Twenty patients were retrospectively studied. Results. The female/male ratio was 3:1, the median age was 36.7 years (range, 16 to 39 years), and the median MELD score was 18.5. According to serological analysis, 19 patients were AIH type 1 and one patient was AIH type 2. AIH was associated with human leukocyte antigen (HLA) DR13+ and DR4+. The overall 5-year patient and graft survival rates were 94 and 85%, respectively. Three (15.7%) cases of recurrent AIH were diagnosed based on histological evidence. Clinical and histological features of acute and chronic rejection were present in four (20%) and three (16.6%) patients, respectively. Conclusion. AIH frequently affected young women, was the most frequent indication for liver transplantation. Rejection and recurrence were commonly associated with AIH, but did not affect patient survival. No significant relationship between HLA-DR type and recurrence was found. Rapid progression to cirrhosis should be considered in severe recurrences.
Start page
222
End page
227
Volume
11
Issue
2
Language
English
OCDE Knowledge area
Gastroenterología, Hepatología
Scopus EID
2-s2.0-84856847883
PubMed ID
Source
Annals of Hepatology
Resource of which it is part
Annals of Hepatology
ISSN of the container
16652681
Sources of information: Directorio de Producción Científica Scopus