The qualitative aspects of the phase diagram of the Ising model on the cubic lattice, with ferromagnetic (F) nearest-neighbor interactions (J 1) and antiferromagnetic (AF) next-nearest-neighbor couplings (J 2) are analyzed in the plane temperature versus , where = J 2/|J1| is the frustration parameter. We used the original Wang-Landau sampling (WLS) and the standard Metropolis algorithm to confront past results of this model obtained by the effective-field theory (EFT) for the cubic lattice. Our numerical results suggest that the predictions of the EFT are in general qualitatively correct, but the lowerature re-entrant behavior, observed in the frontier separating the F and the collinear order, is an artifact of the EFT approach and should disappear when we consider Monte Carlo (MC) simulations of the model. In addition, our results indicate that the continuous phase transition between the F and the paramagnetic (P) phases, that occurs for 0.0 ≤< 0.25, belongs to the universality class of the three-dimensional pure Ising Model. © 2013 World Scientific Publishing Company.