Title
Combined lung and liver procurement in controlled donation after circulatory death using normothermic abdominal perfusion. Initial experience in two Spanish centers
Date Issued
01 January 2020
Access level
open access
Resource Type
journal article
Author(s)
Miñambres E.
Ruiz P.
Ballesteros M.A.
Álvarez C.
Cifrián J.M.
Atutxa L.
Ventoso A.
Castillo F.
Gastaca M.
Publisher(s)
Blackwell Publishing Ltd
Abstract
Combining simultaneously lung and liver procurement in controlled donation after circulatory death (cDCD) using normothermic abdominal perfusion (NRP) for abdominal grafts and cooling and rapid recovery technique (RR) for the lungs increases the complexity of the procurement procedure and might injure the grafts. A total of 19 cDCDs from two centers using this combined procedure were evaluated, and 16 liver and 21 lung transplantations were performed. As controls, 34 donors after brain death (DBDs) were included (29 liver and 41 lung transplantations were performed). Two cDCD liver recipients developed primary nonfunction (12.5%). No cases of ischemic cholangiopathy were observed among cDCD recipients. The 1-year and 2-year liver recipients survival was 87.5% and 87.5% for the cDCD group, and 96% and 84.5% for the DBD group, respectively (P =.496). The 1-year and 2-year lung recipients survival was 84% and 84% for the cDCD group and 90% and 90% for the DBD group, respectively (P =.577). This is the largest experience ever reported in cDCD with the use of NRP combined with RR of the lungs. This combined method offers an outstanding recovery rate and liver and lung recipients survival comparable with those transplanted with DBDs. Further studies are needed to confirm our findings.
Start page
231
End page
240
Volume
20
Issue
1
Language
English
OCDE Knowledge area
Inmunología
Trasplante
Subjects
Scopus EID
2-s2.0-85077296965
PubMed ID
Source
American Journal of Transplantation
ISSN of the container
16006135
Sponsor(s)
This work was supported, in part, by the Fundación Mutua Madrileña (FMM 16/05). The funder did not have a role in study design, data collec‐ tion and analysis, decision to publish, or preparation of the manuscript. We thank Hospital Universitario Puerta de Hierro, Hospital Universitario Vall dE?HebronH,ospital Universitario La Few, Hospital Universitario Reina Sofia, Complexo Hospitalario Universitario A CoruD? Ha,ospital Universitario de Santiago, Hospital Universitario de Asturias, Clinica Universitaria de Navarra, and Hospital Universitario Río Hortega for their help in obtaining data from their lung and liver recipients.
This work was supported, in part, by the Fundación Mutua Madrileña (FMM 16/05). The funder did not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Hospital Universitario Puerta de Hierro, Hospital Universitario Vall d′Hebron, Hospital Universitario La Few, Hospital Universitario Reina Sofia, Complexo Hospitalario Universitario A Coruña, Hospital Universitario de Santiago, Hospital Universitario de Asturias, Clinica Universitaria de Navarra, and Hospital Universitario Río Hortega for their help in obtaining data from their lung and liver recipients.
Sources of information:
Directorio de Producción Científica
Scopus