In this study, a novel stochastic computational frameworks based on fractional Meyer wavelet artificial neural network (FMW-ANN) is designed for nonlinear-singular fractional Lane-Emden (NS-FLE) differential equation. The modeling strength of FMW-ANN is used to transformed the differential NS-FLE system to difference equations and approximate theory is implemented in mean squared error sense to develop a merit function for NS-FLE differential equations. Meta-heuristic strength of hybrid computing by exploiting global search efficacy of genetic algorithms (GA) supported with local refinements with efficient active-set (AS) algorithm is used for optimization of design variables FMW-ANN., i.e., FMW-ANN-GASA. The proposed FMW-ANN-GASA methodology is implemented on NS-FLM for six different scenarios in order to exam the accuracy, convergence, stability and robustness. The proposed numerical results of FMW-ANN-GASA are compared with exact solutions to verify the correctness, viability and efficacy. The statistical observations further validate the worth of FMW-ANN-GASA for the solution of singular nonlinear fractional order systems.