Title
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines
Date Issued
15 January 2008
Access level
metadata only access
Resource Type
journal article
Author(s)
Valderrama J.
Rivera F.
Rojo L.
Campos N.
Pedro M.
José Nascimento M.
Universidad Arturo Prat
Abstract
The preparation of furyl-1,4-quinone and hydroquinones by reaction of 2-furaldehyde N,N-dimethylhydrazone with benzo- and naphthoquinones is reported. Access to furylnaphthoquinones from unactivated quinones requires acid-induced conditions, however oxidative coupling reactions of activated quinones proceed under neutral conditions. The in vitro cytotoxic activity of the prepared compounds against a panel of three human cancer cell lines has been studied. Most of the furyl-1,4-quinones exhibited good antiproliferative activity (GI50 = 6.5-33.5 μm) against the MCF-7, NCI-H460, and SF-268 (CNS cancer) cell lines chosen for testing. © 2007 Elsevier Ltd. All rights reserved.
Start page
862
End page
868
Volume
16
Issue
2
Language
English
OCDE Knowledge area
Química
Subjects
Scopus EID
2-s2.0-38549171048
PubMed ID
Source
Bioorganic and Medicinal Chemistry
ISSN of the container
09680896
Sponsor(s)
Financial support by FONDECYT (Grant 1020885), FCT (I& D N° 226/94), POCTI (QCA III), and FEDER is gratefully acknowledged. Madalena Pedro is a recipient of a PhD grant from FCT (SFRH/BD/1456/2000). The authors thank the National Cancer Institute, Bethesda, MD (USA), for kindly providing the tumor cell lines.
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