Cryptococcus neoformans is a ubiquitous dimorphic fungus that can be life threatening, especially in immunocompromised hosts. It commonly infects the respiratory tract and central nervous system. However, skin manifestations may be a marker of severe and disseminated disease; therefore, early diagnosis is crucial. In this case we report a 34- year-old man with acquired immunodeficiency syndrome who developed molluscum contagiosum-like lesions on the face and upper limbs. He was hospitalized for headache and vomiting. Examination of the skin and cerebrospinal fluid revealed numerous encapsulated yeast identified as Cryptococcus neoformans.