Objective Oncoplastic surgery is a type of breast conservation surgery, which allows oncologic resection and breast remodelling in the same surgical procedure. It is now widely used in Latin America, but large studies of its results are lacking. The aim of this study was to evaluate the safety of oncoplastic surgery in the treatment of invasive breast cancer. Method A total of 124 patients who underwent oncoplastic surgery between 2007 and 2015 for non-metastatic invasive breast cancer (study group) were retrospectively compared with 302 patients who underwent conventional (non-oncoplastic surgery) breast conservation surgery (control group) in the same period. Results The mean length of follow-up was 61 months. Overall survival and disease-free survival was higher in the oncoplastic surgery group than in the control group at 10 years (97.7 vs. 89.8%, P =.04; 93 vs. 86.7% at 10 years, P =.05). Discussion We compared patients who had oncoplastic primary surgery for non-metastatic invasive breast cancer (n = 124) with a control (n = 302) group who were followed-up for a long period, providing evidence to suggest that oncoplastic surgery is a safe and reliable treatment option in patients with breast cancer in Latin America.