Title
Cordiasecosides G-J, 9,10-Seco-29-norcycloartane glycosides isolated from Cordia lutea and their antibacterial activities
Date Issued
01 April 2022
Access level
open access
Resource Type
journal article
Author(s)
André-Barrès C.
Fabre N.
Massou S.
Castillo Pareja D.
Jullian V.
Publisher(s)
Elsevier B.V.
Abstract
Four undescribed secocycloartane monoglycosides (1–4) were isolated from an ethanolic extract of the dry flowers of Cordia lutea Lam. Their structural assignment is based on NMR and MS analysis. Their stereochemistry is confirmed by molecular modelling studies using DFT-NMR calculations done for compound 3. In vitro antibacterial activity of the four compounds was moderate on Helicobacter pylori (MIC = 15.6 μg/mL), and much weaker on Staphylococcus aureus, Pseudomonas aeruginosa or Escherichia coli (MIC >125 μg/mL). Toxicity evaluated against RAW 264.7 cells was weak (IC50 values ranging from 24 to 41 μM i.e. 15 to 24 μg/mL), but in the same range as anti-Helicobacter activity.
Volume
158
Language
English
OCDE Knowledge area
Farmacología, Farmacia
Subjects
Scopus EID
2-s2.0-85126467500
PubMed ID
Source
Fitoterapia
ISSN of the container
0367326X
Sponsor(s)
I.C. thanks the Institut de Recherche pour le Développement (IRD) for the award of a grant “ Allocations de Recherche pour une Thèse au Sud ” (ARTS). The authors thank the logistic support of the LMI-LaVi ( UPCH,IRD , Lima, Peru) and their directors: Pr. Rosario Rojas (UPCH) and Dr. Michel Sauvain (IRD). The authors are grateful to Pierre Lavedan, Marc Vedrenne and Caroline Toppan (NMR platform of the Institut de Chimie de Toulouse , ICT) for NMR analyses. The authors are indebted to the personnel of Universidad Nacional Mayor de San Marcos , Lima, Peru, (UNMSM) herbarium for plant determination and the Servicio Nacional Forestal y de Fauna Silvestre (SERFOR) for issuing the C. lutea collecting and research permits (No 146-2016-SERFOR/DGGSPFFS ).
I.C. thanks the Institut de Recherche pour le D?veloppement (IRD) for the award of a grant ?Allocations de Recherche pour une Th?se au Sud? (ARTS). The authors thank the logistic support of the LMI-LaVi (UPCH,IRD, Lima, Peru) and their directors: Pr. Rosario Rojas (UPCH) and Dr. Michel Sauvain (IRD). The authors are grateful to Pierre Lavedan, Marc Vedrenne and Caroline Toppan (NMR platform of the Institut de Chimie de Toulouse, ICT) for NMR analyses. The authors are indebted to the personnel of Universidad Nacional Mayor de San Marcos, Lima, Peru, (UNMSM) herbarium for plant determination and the Servicio Nacional Forestal y de Fauna Silvestre (SERFOR) for issuing the C. lutea collecting and research permits (No 146-2016-SERFOR/DGGSPFFS).
Sources of information:
Directorio de Producción Científica
Scopus