Two new species of Pentacalia are described herein on the basis of morphological evidence. These new findings are the result of field work and recent herbarium studies carried out at USM. Both species are very distinctive and any confusion with the other known taxa of the genus is unlikely. Both species are hitherto only known from the type locality, one collected in Junín Department (central Peru) and the other in Amazonas Department (northern Peru). They grow in Andean humid montane forests. Pictures of the respective holotypes and a distribution map are provided. Moreover, the name P. marinii is synonymized under P. herzogii, as well as P. megaphlebia to P. oronocensis.