Retrofitting and management strategies of existing buildings are actually a crucial topic. In this work, an approach based on GIS and MCDM method has been used in order to define a retrofitting ranking for seismic risk management. The main goal is to define a framework based on a multidisciplinary approach. The proposed procedure can be used in different ways and applications. It can be the basis of seismic risk mitigation strategies which are a typical problem of public administrations. Due to both the amount of essential buildings that require seismic retrofitting and the restricted economic availability, it is necessary to prioritize interventions on large territorial scale in order to optimize the allocation of available economic resources and ensure an efficient seismic risk mitigation. The paper provides a simple and rational seismic risk mitigation policy in order to consider the possible variables or disciplines that are not generally integrated in studies of risk (not only seismic) on a large territorial scale.