Magnetic hyperthermia is becoming a very propitious supplementary technique for cancer treatments such as chemotherapy radiotherapy and radiotherapy. In this regard, magnetic nanoflowers (MNFs) are novel system in terms of morphology showing a structure similar to flower and exhibiting higher stability and enhanced heating efficiency when compared with similar nanoparticles displaying standard formats; enabling them for magneto-hyperthermia applications. In this chapter, different types of nanoflowers such as magnetic-oxide, magneto-plasmonic, and magnetic-organic/inorganic and their applicability are discussed. Moreover, a discussion on the most common chemical routes to design nanoflowers emphasizing hydro/solvothermal techniques, microwave-assisted hydrothermal, co-precipitations, and polyol are highlighted. Furthermore, the nucleation of MNFs and their growing process with a physical parameter are presented. At last, the magnetic hyperthermia properties of MNFs and their recent findings are critically scrutinized along with their future perspectives in biomedicine.