Primary failure of eruption (PFE) is an autosomal disease that occurs in approximately 0.06% of the population and is defined as the malfunction of dental eruptive mechanisms with delay and absence of these processes in a non-ankylosed tooth. Treatment options for patients with eruptive delays range from prosthetic to surgical interventions. Although this condition is relatively rare, the occurrence of eruptive disorders in clinical dental practice is becoming more frequent. Correct diagnosis of this eruptive anomaly plays an essential role in treatment planning. The aim of this case report was to describe the treatment of a case of multiple PFE with a biomechanical approach to extrusive traction using NiTi closed coil springs and a customized rigid anchorage. In conclusion, complex orthodontic cases with eruptive delay and variants of PFE can be successfully intervened to make morphologically and functionally compromised dental organs viable, if diagnosed and treated in a timely and preventive manner by a multidisciplinary approach using alternative biomechanics for efficient osteogenic traction.