Title
Efficacy and safety of 10‐deazaaminopterin in the treatment of rheumatoid arthritis: A one‐year continuation, double‐blind study
Date Issued
01 January 1992
Access level
metadata only access
Resource Type
journal article
Publisher(s)
John Wiley & Sons
Abstract
Objective. To determine the long‐term safety and efficacy of 10‐deazaaminopterin (10‐DAM) in the treatment of rheumatoid arthritis (RA). Methods. A 1‐year continuation of an initial 15‐week randomized, double‐blind clinical trial of 10‐DAM and methotrexate (MTX). Results. 10‐DAM (n = 10) and MTX (n = 8) had comparable safety and efficacy profiles. One 10‐DAM—treated and 2 MTX‐treated patients experienced transient side effects; 1 MTX‐treated patient experienced recurrent nausea and discontinued MTX. Conclusion. 10‐DAM appears to be as beneficial and as safe as MTX for the treatment of RA. Copyright © 1992 American College of Rheumatology
Start page
1318
End page
1321
Volume
35
Issue
11
Language
English
OCDE Knowledge area
Reumatología
Nutrición, Dietética
Publication version
Version of Record
Scopus EID
2-s2.0-0026545726
PubMed ID
Source
Arthritis & Rheumatism
ISSN of the container
0004-3591
Sponsor(s)
National Institute of Allergy and Infectious Diseases P01AI018745
Sources of information:
Directorio de Producción Científica
Scopus