Objective: To determine the relationship of medication abuse and anxiety symptoms in adult outpatients with chronic migraine in the SANNA / Sánchez Ferrer Clinic, Trujillo-Peru. Material And Method: Cross-sectional study, with a sample of 104 patients with chronic migraine with and without medication abuse. Absolute, relative, average and SD frequencies are reported according to the type of variable. In the bivariate analysis through the Chi2 of Homogeneity and level of the multivariate analysis, using regression of Generalized Linear Models, Poisson and Poisson family with robust variance. Results: We found 96 (92.3%) female patients, with a mean age and SD 37.1 ± 9.6. Overall, 1 in 3 patients had anxiety symptoms and 1 in 2 patients reported medication abuse. The proportion of patients with anxiety symptoms was three times higher in the group with medication abuse than those without medication abuse. Outpatients with chronic migraine who abuse medications are 2.28 times more at risk of anxiety symptoms than those who do not abuse medications. Conclusions: Outpatients with chronic migraine who abuse medications have a higher risk of anxiety symptoms. Therefore, it is necessary to incorporate psychological support to all patients with medication abuse and prevent side effects of that abuse.