Introduction: The COVID-19 pandemic is generating changes in health organizations and front-line healthcare workers, who should take assertive decisions so that their leadership in their work teams is effective in the face of any situation. Objective: Determine the relationship between leadership style and attitude toward organizational change among professionals during the COVID-19 pandemic, applying a health technology approach. Methods: A descriptive prospective correlational study was conducted of 215 qualified collegiate pharmaceutical chemists from the public and the private sectors who have access to information systems to conduct the drug supply management process. The first variable was measured with the Multifactor Leadership Questionnaire (MLQ) 5X short form and the second with the questionnaire of attitude toward organizational change. Both tools applied the Likert scale and were evaluated for validity and reliability to adapt them to the Peruvian context. Results: Pharmaceutical chemistry professionals showed to have a medium level in both leadership style and attitude toward organizational change. However, inferential analysis revealed a direct significant relationship between the study variables. Conclusions: The moderate levels of transactional, transformational, corrective and passive / avoidant styles may be improved to achieve optimum leadership capable of dealing with transformations with better acceptance levels, preventing resistance to organizational change.