The objective of this study was to identify the factors that influence learning in technology management and innovation in management students in Medellin (Colombia) through the model of technological acceptance. A quantitative and correlational methodology was used, based on an exploratory factor analysis and a confirmatory factor analysis. Information was collected with a questionnaire based on the Likert scale and a survey was applied to a sample of 411 students. The results showed the importance of self-efficacy, userfriendliness and perceived utility as drivers of learning processes and acceptance of the value of technology and innovation management. However, there are still some gaps in the training processes, such as lack of subjects, contents and sufficient information around the subject. It is concluded that relevant training in this field can be decisive to increase the employability of management professionals and to increase the contribution to the improvement of business competitiveness and sustainability.