Title
Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru
Date Issued
01 July 2012
Access level
metadata only access
Resource Type
review
Author(s)
Universidad Politécnica de Cataluña
Abstract
Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type structured hazard regression models while accounting for potential spatial correlations in the survival times. We identified eight covariates with significant effect for overall survival. Some of them are widely known such as age, performance status, clinical stage and lactic dehydrogenase, but we also identified hemoglobin, leukocytes and lymphocytes as covariates with a significant effect on the overall survival of patients with NHL. Besides, the effect of continuous covariates is clearly nonlinear and hence impossible to detect with the classical Cox method. Although the spatial component does not show a significant effect, the results show a trend of low risk in certain areas.
Start page
221
End page
230
Volume
36
Issue
2
Language
English
OCDE Knowledge area
Políticas de salud, Servicios de salud
Subjects
Scopus EID
2-s2.0-84873687148
Source
SORT
ISSN of the container
20138830
Sources of information:
Directorio de Producción Científica
Scopus