A new species of Senecio L. from the central Andes of Peru, S. carhuanishoensis H.Beltrán & J.Calvo sp. nov., only known from the Laraos District (Yauyos, Lima), is described and illustrated. It is a suffrutescent, rupicolous plant with the stems rather appressed to the rocks. It is characterized by its greyish-lanate indumentum covering the stem, leaves, and involucre, by having leaves oblanceolate to oblong, short-pedunculate, terminal, solitary, discoid capitula, and by displaying short glandular trichomes between the throat and the tube of the florets. It strictly grows in limestone rock crevices. Its morphology is compared with those of S. evacoides Sch.Bip. and S. ishcaivilcanus Cuatrec.