Innovation, technology and entrepreneurship play an important role in the development of a country’s economy, especially in the health sector. The vision of entrepreneurs and innovators in this sector has led to significant advances in patient management and improvements in health products and services, especially in the context of the health crisis due to COVID-19. This article aims to identify research related to technology, innovation and entrepreneurship in the health sector from a literature. A total of 19 articles published in the 2016-2021 period were selected. The results show that people’s creativity enables entrepreneurship and the generation of innovative proposals in health services. Likewise, technologies such as blockchain, machine learning, virtual reality and artificial intelligence have been used to generate value proposals in this sector.