Title
Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
Other title
Síntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosis
Síntese de acilhidrazona a partir de ácido úsnico e isoniazida e sua atividade anti-Mycobacterium tuberculosis
Date Issued
01 January 2017
Access level
open access
Resource Type
journal article
Author(s)
Publisher(s)
Universidad Nacional de Colombia
Abstract
Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.
Start page
17
End page
21
Volume
46
Issue
3
Language
English
OCDE Knowledge area
Química medicinal
Enfermedades infecciosas
Ingeniería química
Nutrición, Dietética
Subjects
Scopus EID
2-s2.0-85029348693
Source
Revista Colombiana de Quimica
ISSN of the container
01202804
Sources of information:
Directorio de Producción Científica
Scopus