Title
Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
Date Issued
01 March 2021
Access level
open access
Resource Type
review
Author(s)
Bousquet J.
Anto J.M.
Czarlewski W.
Haahtela T.
Fonseca S.C.
Iaccarino G.
Blain H.
Vidal A.
Sheikh A.
Akdis C.A.
Zuberbier T.
Hamzah Abdul Latiff A.
Abdullah B.
Aberer W.
Abusada N.
Adcock I.
Afani A.
Agache I.
Aggelidis X.
Agustin J.
Akdis M.
Al-Ahmad M.
Al-Zahab Bassam A.
Alburdan H.
Aldrey-Palacios O.
Alvarez Cuesta E.
Alwan Salman H.
Alzaabi A.
Amade S.
Ambrocio G.
Angles R.
Annesi-Maesano I.
Ansotegui I.J.
Ara Bardajo P.
Arasi S.
Arshad H.
Cristina Artesani M.
Asayag E.
Avolio F.
Azhari K.
Bachert C.
Bagnasco D.
Baiardini I.
Bajrović N.
Bakakos P.
Bakeyala Mongono S.
Balotro-Torres C.
Barba S.
Barbara C.
Barbosa E.
Barreto B.
Bartra J.
Bateman E.D.
Battur L.
Bedbrook A.
Bedolla Barajas M.
Beghé B.
Bekere A.
Bel E.
Ben Kheder A.
Benson M.
Berghea E.C.
Bergmann K.C.
Bernardini R.
Bernstein D.
Bewick M.
Bialek S.
Białoszewski A.
Bieber T.
Billo N.E.
Bilo M.B.
Bindslev-Jensen C.
Bjermer L.
Bobolea I.
Bochenska Marciniak M.
Bond C.
Boner A.
Bonini M.
Bonini S.
Bosnic-Anticevich S.
Bosse I.
Botskariova S.
Bouchard J.
Boulet L.P.
Bourret R.
Bousquet P.
Braido F.
Briggs A.
Brightling C.E.
Brozek J.
Brussino L.
Buhl R.
Bumbacea R.
Buquicchio R.
Burguete Cabañas M.T.
Bush A.
Busse W.W.
Buters J.
Caballero-Fonseca F.
Calderon M.A.
Publisher(s)
John Wiley and Sons Inc
Abstract
Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.
Start page
735
End page
750
Volume
76
Issue
3
Language
English
OCDE Knowledge area
Inmunología
Subjects
Scopus EID
2-s2.0-85090726397
PubMed ID
Source
Allergy: European Journal of Allergy and Clinical Immunology
ISSN of the container
01054538
Sources of information:
Directorio de Producción Científica
Scopus