In many parts of the world, people suffer from different micronutrient deficiencies due to the same aetiology of micronutrient deficiency and physiological interactions between the micronutrient metabolisms. To reduce and alleviate micronutrient deficiencies, supplementation programmes for different micronutrients are often implemented simultaneously. Since operational strategies and distribution systems can be similar for each micronutrient, efforts and resources are duplicated and cost-effectiveness is therefore reduced. Widespread micronutrient deficiencies in populations have a deep-rooted causality within the life cycle of people. They are strongly associated with poverty and are passed from one generation to the next. Recently, multi-micronutrient supplementation has been suggested to break this vicious circle of micronutrient deficiencies within the life cycle. However, several technical and scientific aspects have to be considered for the implementation of a multi-micronutrient supplementation programme.