Title
A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates
Date Issued
01 June 2005
Access level
metadata only access
Resource Type
journal article
Author(s)
Hospital Clínic
Abstract
The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation. © 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Start page
542
End page
545
Volume
25
Issue
6
Language
English
OCDE Knowledge area
Enfermedades infecciosas
Genética humana
Subjects
Scopus EID
2-s2.0-19544371363
PubMed ID
Source
International Journal of Antimicrobial Agents
ISSN of the container
09248579
Sponsor(s)
This work has been partially supported by grants FIS02/0353 from the Ministry of Health, Spain, and 2002 SGR00121 from the Departament d’Universitats, Recerca I Societat de la Informació de la Generalitat de Catalunya, Spain. J.R. has a fellowship from RICET.
Sources of information:
Directorio de Producción Científica
Scopus