Title
Biodegradable polylactide scaolds with pharmacological activity by means of ultrasound micromolding technology
Date Issued
01 May 2020
Access level
open access
Resource Type
journal article
Author(s)
Universitat Politècnica de Catalunya
Publisher(s)
MDPI AG
Abstract
Ultrasound micromolding technology has been applied to get microporous polylactide scaolds from the subsequent leaching of incorporated NaCl salts. A small amount of water-soluble polyethylene glycol (PEG) was required in order to improve the leaching process and get compact pieces with interconnected pores. Distribution of polymers in the processed specimens was quite homogeneous due to the small PEG content, although it was more concentrated in the regions close to the feeding channels due to its higher viscosity. Hydrophobic drugs like triclosan could be incorporated causing a minimum degradation during ultrasound processing and suering an insignificant solubilization during the leaching step. Final scaolds showed clear bactericide or bacteriostatic eects before and after 10 h of exposure. Cell proliferation of MDCK epithelial cells was higher for TCS loaded porous scaolds (200%) than for unloaded samples (170%) and non-porous polylactide (PLA) specimens (100%, control). Micrographs showed the absence of non-inhibition areas in both the specimens and the container, confirming the biocompatibility of PLA specimens.
Volume
10
Issue
9
Language
English
OCDE Knowledge area
Farmacología, Farmacia
Ingeniería química
Subjects
Scopus EID
2-s2.0-85085108667
Source
Applied Sciences (Switzerland)
ISSN of the container
20763417
Sponsor(s)
The authors are in debt to support from MINECO and FEDER (RTI2018-101827-B-I00) and the Generalitat de Catalunya (2017SGR373).
Sources of information:
Directorio de Producción Científica
Scopus