‘Panhandle Pride’ (Reg. no. CV-325, PI 691461) great northern common bean (Phaseolus vulgaris L.) cultivar was developed by the dry bean breeding program at the University of Nebraska and released in 2016. It was bred specifically for adaptation to western Nebraska growing conditions and for enhanced resistance to bean rust and common bacterial blight (CBB). Seed yield of Panhandle Pride was comparable to the other cultivars in the on-station and on-farm trials conducted in Nebraska and was greater than ‘Orion’ and lower than ‘Matterhorn’ in regional trials. Seed size (100-seed weight) for Panhandle Pride was larger than Marquis and Beryl-R in trials grown in Nebraska, and larger than Orion and Matterhorn in regional trials. Panhandle Pride carries the sequence characterized amplified region (SCAR) markers SAP6 and SU91 linked to a major CBB resistance quantitative trait locus, and its reaction to the CBB pathogen under field conditions was consistent across 3 yr at the West Central Research and Extension Center, North Platte, NE, with disease ratings of 6.0, 4.3, and 5.2. Panhandle Pride has the Ur-3 and Ur-6 genes for resistance to bean rust and carries the SS68 Kompetitive Allele Specific polymerase chain reaction (KASP) and SK14 SCAR markers linked the Ur-3 bean rust resistance locus. It also carries the single dominant hypersensitive I gene that provides resistance to all non-necrotic strains of the Bean common mosaic virus (BCMV) and the SW13 SCAR marker linked to the I gene for resistance to BCMV. Panhandle Pride has bright white seed, blooms 44 d after planting, and is a midseason bean, maturing 87 d after planting.