Aim: To determine the association between social, physiological factors and the risk of cardiovascular event according to the Framingham Risk Score, in taxi drivers of a transport company in the city of Huancayo-Peru. Methodology: An observational cross-sectional study in a taxi transport company of Huancayo was performed, by a non-probability sampling. Data were collected to generate the Framingham Score (version 1991), calculating the cardiovascular risk within 10 years, in addition to collect other variables such as physical activity, diet, alcohol consumption, family history and triglycerides. P values were obtained. Results: The risk of suffering a cardiovascular event within 10 years, according to the Framingham tables is low in 88% of cases. The value of fasting glucose was statistically different between those with a high category of cardiovascular risk (p = 0.013) in addition, having diagnosed diabetes was also statistically different (p = 0.027). Conclusions: There is a low level of cardiovascular risk at 10 years in taxi drivers in the city of Huancayo. These findings may help Public and Occupational Health, to care for these populations that are at risk and that could have an impact on morbidity and mortality in the future.