Globally we are going through a difficult situation due to this pandemic due to COVID-19, one of the most effective measures implemented by most governments has been social isolation, which can cause psychosocial risk; The objective of this study is to evaluate the psychosocial well-being of the students of a Peruvian public university during the 90 days of social isolation; the method we have used is descriptive - cross-sectional, with a non-probability sample of 285 university students, who filled out an online survey to detect psychosocial symptoms, using the General Health Questionnaire (GHQ-28); finding that 72.6% of students exposed to a medium-high level of psychosocial risk. In conclusion, an association was found between a medium-high level of psychosocial risk and the variables: cohabiting with people at risk for COVID-19 (Xi2 = 9,661 and p <0.05); present symptoms compatible with COVID-19 19 (Xi2 = 28,957 and p <0.05) and cohabit with COVID-19 patients (Xi2 = 8,803 and p <0.05).