Title
Characterization of the interaction between the saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54
Date Issued
26 July 2013
Access level
open access
Resource Type
journal article
Author(s)
New York University School of Medicine
Abstract
Background: Rdh54 is a motor protein that is able to dissociate Rad51 recombinase from chromatin. Results: The Rad51-binding domain of Rdh54 resides within its N terminus and is required for Rad51 removal from DNA. Conclusion: Rdh54-Rad51 interaction is important for Rad51 dissociation from chromatin but not for DNA repair. Significance: Rdh54 inhibits accumulation of toxic Rad51-DNA complexes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Start page
21999
End page
22005
Volume
288
Issue
30
Language
English
OCDE Knowledge area
BioquÃmica, BiologÃa molecular
Scopus EID
2-s2.0-84881249017
PubMed ID
Source
Journal of Biological Chemistry
ISSN of the container
1083351X
Sponsor(s)
National Cancer Institute - R01CA146940 - NCI
Sources of information:
Directorio de Producción CientÃfica
Scopus