Twitter became the most popular form of social interactions in the healthcare domain. Thus, various teams have evaluated Twitter as an additional source where patients share information about their healthcare with the potential goal to improve their outcomes. Several existing topic modeling and document clustering applications have been adapted to assess tweets showing that the performances of the applications are negatively affected due to the nature and characteristics of tweets. Moreover, Twitter health research has become difficult to measure because of the absence of comparisons between the existing applications. In this paper, we perform an evaluation based on internal indexes of different topic modeling and document clustering applications over two Twitter health-related datasets. Our results show that Online Twitter LDA and Gibbs LDA get a better performance for extracting topics and grouping tweets. We want to provide health practitioners this comparison to select the most suitable application for their tasks.