Introduction: Burnout Syndrome (SB) has been studied in large numbers of professional people, but in our environment do not yet have reports on students of health sciences. The objective was to determine the prevalence of SB and factors associated in seven peruvianmedicine schools. Methods: Analytical, multicenter cross-sectional study. Through a self-applied to students who came to hospital offices in seven medical schools survey Peru. SB was defined as the positive test Maslach Burnout Inventory (MBI), besides other socio-educational and habits was measured variables. P values were obtained using generalized linear models, adjusting for the university of origin. Results: Of the 557, the median age was 22 years (interquartile range: 21-24 years), 50% (278) were women. 8% (47) had positive SB, ranging 1-22% depending on the seat of respondent, increasing its prevalence increases as the year of study, 3% (3rd), 9% (4th), 13% (5th) and 12% (6th). The variables that increased the frequency of SB were coursing the last two years prior to boarding school (p < 0.001) and smoking (p < 0.001); conversely, the more hours of study (p = 0.047) reduced the frequency of SB, adjusted for sex. Conclusions: A low frequency of SB among students was found, however, it is important to know which factors are related, to intervene in search of improving the mental health of future health professionals.