Title
MnPS3 shows anticancer behaviour towards lung cancer cells
Date Issued
01 November 2019
Access level
metadata only access
Resource Type
journal article
Author(s)
Mohamad Latiff N.
Rosli N.F.
Szokolava K.
Sofer Z.
Fisher A.C.
Pumera M.
University of Chemistry and Technology Prague
Publisher(s)
Elsevier B.V.
Abstract
Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.
Volume
18
Language
English
OCDE Knowledge area
Oncología
Biología celular, Microbiología
Subjects
Scopus EID
2-s2.0-85073745346
Source
FlatChem
ISSN of the container
24522627
Sponsor(s)
A. C. F., N. M. L. and N. F. R. were funded by Singapore’s National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S ) and Neuron Foundation for Science . Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X ).
Sources of information:
Directorio de Producción Científica
Scopus