The muscular overtiredness can be defined as the incapacity to raise a level of the muscular strength or a determined intensity of exercise in a situation where athletes experiment efforts. According to the multifactor design of the overtiredness, the mechanisms involved in such a weakened state still remain unclear. With regard to a functional standpoint, this research is dedicated to consider both the central tiredness (nervous system) and the peripheral tiredness (neuromuscular system). The purpose of this study was to review the literature dedicated to the mechanisms involved in the explanation of the overtiredness with regard to various variables needed to be considered.