Title
Skeletal muscle adiposity and outcomes in candidates for lung transplantation: A lung transplant body composition cohort study
Date Issued
01 September 2020
Access level
open access
Resource Type
journal article
Author(s)
Anderson M.R.
Easthausen I.
Gallagher G.
Udupa J.
Tong Y.
Torigian D.
Diamond J.M.
Porteous M.K.
Palmer S.M.
Snyder L.D.
Benvenuto L.
Aversa M.
Arcasoy S.
Greenland J.R.
Hays S.R.
Kukreja J.
Cantu E.
Kim J.S.
Gallagher D.
Barr R.G.
Lederer D.J.
Christie J.D.
Singer J.P.
Medicine Columbia University Medical Center
Publisher(s)
BMJ Publishing Group
Abstract
CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification.
Start page
801
End page
804
Volume
75
Issue
9
Language
English
OCDE Knowledge area
Cirugía
Subjects
Scopus EID
2-s2.0-85089787848
PubMed ID
Source
Thorax
ISSN of the container
00406376
Sponsor(s)
Contributors Study design: MRA, IE, DJL, JC and JPS. Data acquisition, analysis, interpretation: MRA, IE, GG, JU, YT, DT, JMD, MKP, SMP, LDS, LB, MA, SA, JRG, SRH, JK, EC, JSK, DG, MRB, RGB, DJL, JC and JPS. First draft of the manuscript: MRA, IE, JC and JPS. Final manuscript review and approval: all authors. Funding Supported by National Institutes for Health Grants: T32 HL105323, K24 HL131937, R01 HL 114626, R01 HL 134851, R01 HL 087115, K24 HL115354, Stony Wold-Herbert Foundation, VA-ORD: IK2 CX001034.
Sources of information:
Directorio de Producción Científica
Scopus