Introduction: There are some studies on the benefits of ZhiNeng QiGong, but still very few in the context of the COVID-19 pandemic and related to holistic care. Objective: To describe the benefits of Zhineng Qigong in the comprehensive health of practicing adults during COVID-19. Method: Exploratory descriptive qualitative research. The sample was non-probabilistic for convenience, achieved by the saturation technique and data redundancy, 13 practitioners of the third International Certification of Zhineng Qigong participated, with prior informed consent. The information was collected by online interview and processed according to content analysis. Results: Five categories were found: physical health, mental health, social health, spiritual health and ecological health, where positive changes were found for strengthening and individual healing with irradiation towards their family and social environment. Conclusions: All Zhineng Qigong practitioners experienced physical and emotional healing, improvements in their family and work relationships. Likewise, they feel vitality, inner peace, connection with the universe and nature. Most indicated that they did not contract COVID-19 because they improved their immune system and breathing with the practice. © 2023 Universidad de Alicante. All rights reserved.