Title
Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru
Date Issued
01 February 2008
Access level
open access
Resource Type
journal article
Author(s)
Zhou Z.
Griffing S.M.
De Oliveira A.M.
McCollum A.M.
Quezada W.M.
Escalante A.A.
Udhayakumar V.
Abstract
The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Start page
739
End page
741
Volume
52
Issue
2
Language
English
OCDE Knowledge area
Farmacología, Farmacia
Parasitología
Scopus EID
2-s2.0-38649109842
PubMed ID
Source
Antimicrobial Agents and Chemotherapy
ISSN of the container
00664804
Sources of information:
Directorio de Producción Científica
Scopus