The Clusiaceae are represented in Peru by 21 genera and 137 species (Brako & Zarucchi, 1993; Ulloa Ulloa et al., 2004), mainly trees, shrubs and hemiepiphytes. Here we recognize 22 endemic species in nine genera. Clusia is the genus with the largest number of endemic species. Endemic Clusiaceae are found in the Humid Lowland Amazonian Forests and Very Humid Montane Forests regions, between 100 and 3000 m elevation. We applied IUCN categories and criteria to 11 species. Only four endemic species have been recorded within Peru's protected areas system.