OBJECTIVE: To establish the relationship among age, sex, body mass index, consumption of alcoholic beverages and cigarettes with the inadequate response to the vaccine against Hepatitis B in patients with HIV infection who were treated in the Clinical Unit of Infectious and Tropical Diseases of the Regional Hospital of Trujillo - Peru, from 2014 to 2015. MATERIALS AND METHODS: The study was observational, retrospective, cross-sectional, type cases and controls. RESULTS: In the vaccinated patients, it was found that the age ≥ 50 years old; with OR = 3.4 and CD4 < 200, with OR = 35.0, are the risk factors to get the inadequate response to the vaccine against Hepatitis B. CONCLUSIONS: There is a relationship between the re-count of cells CD4 < 00 and the age over 50 years old with an Inadequate response to the vaccination against hepatitis B in HIV-infected patients in the Regional Hospital of Trujillo.