The DIAdvisor™ is an EC/FP7 funded project aiming at the development of a Blood Glucose prediction device which uses easily available information to optimise the therapy of patients with diabetes. The project will achieve its objectives by developing a unique system for patients with diabetes to help them manage their disease effectively, optimising safety and giving an improved quality of life. One main outcome of DIAdvisor will be to reduce the negative effects of long-term hyperglycaemia with no increased occurrence of hypoglycaemia. A comprehensive clinical database has been established and utilised for systems development. In-silico testing shows promising results. In parallel a device platform has been developed for running these systems. During early 2010 a first prototype has been exposed to extensive in-vitro validation and is now undergoing clinical testing. © 2010 IEEE.