Common bean rust, Bean golden yellow mosaic virus (BGYMV), Bean common mosaic virus (BCMV), and Bean common mosaic necrosis virus (BCMNV) are devastating diseases of dry bean (Phaseolus vulgaris L.) in Central America and the Caribbean. The development of dry bean cultivars with enhanced levels of genetic resistance to these and other diseases is an important goal of the University of Puerto Rico (UPR) and other dry bean breeding programs in Central America and the Caribbean. PR1572-19 (Reg. no. GP-308, PI 692976) and PR1572-26 (Reg. no. GP-307, PI 692975) are multiple virus- and rust-resistant pinto bean germplasm lines adapted to the humid tropics that were developed and released cooperatively in 2019 by the UPR Agricultural Experiment Station, the Instituto Dominicano de Investigaciones Agropecuarias y Forestales, and the USDA–ARS. Both PR1572-19 and PR1572-26 possess the bgm-1 gene for resistance to BGYMV, the I and bc-3 loci that provide broad resistance to all strains of BCMV and BCMNV in the United States and the Caribbean, and the Ur-3 and Ur-11 loci that confer comprehensive resistance to all known races of the bean rust pathogen. PR1572-26 also has the SW12 quantitative trait locus marker associated with resistance to BGYMV. PR1572-19 and PR1572-26 produced mean seed yields similar to the check cultivar ‘Santa Fe’ in trials conducted in Puerto Rico and mean seed yields comparable to the pinto cultivar ‘La Paz’ in the Cooperative Dry Bean Nursery conducted in Puerto Rico. Both lines should serve as useful sources of resistance to BGYMV, BCMV, BCMNV, and bean rust for common beans of the Durango race that includes the pinto and great northern market classes.