Title
Exercise heart rates in patients with hypertrophic cardiomyopathy
Date Issued
01 January 2015
Access level
open access
Resource Type
journal article
Author(s)
Luo H.C.
Dimaano V.L.
Kembro J.M.
Hilser A.
Hurtado-De-Mendoza D.
Pozios I.
Tomas M.S.
Yalcin H.
Aon M.A.
Cameron D.
Bluemke D.A.
Stewart K.J.
Russell S.D.
Cordova J.G.
Abraham T.P.
Abraham M.R.
Johns Hopkins University
Johns Hopkins University
Publisher(s)
Elsevier Inc.
Abstract
The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.
Start page
1144
End page
1150
Volume
115
Issue
8
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Sistema cardiaco, Sistema cardiovascular
Patología
Fisiología
Scopus EID
2-s2.0-84930248808
PubMed ID
Source
American Journal of Cardiology
ISSN of the container
00029149
Sponsor(s)
National Heart, Lung, and Blood Institute - R01HL092985 - NHLBI
This study was supported in part by a grant from the John Taylor Babbit Foundation to MRA.
Sources of information:
Directorio de Producción Científica
Scopus