Five different commercial catalysts, Pt/C, PtRu/C, Pt3Sn/C, Pt3Co/C and Pt3Ni/C, have been used for direct oxidation of glycerol in an alkaline fuel cell. KOH-doped polybenzimidazole was used as electrolyte membrane. The results show that the addition of a less noble secondary metal to platinum enhances the electrocatalytic activity, with an increase in the maximum power density, especially in the case of the PtRu/C and Pt3Sn/C. This result can be explained taking into account that, according to the XRD results, these two catalysts possess a large oxide fraction in its surface. As a consequence, the presence of oxygenated species coming from the second metal is crucial for promoting the glycerol electroxidation.