This chapter makes a novel contribution analyzing the first studies of entrepreneurship by women. Then, it is described the STEM education components that are so relevant for the understanding of the current educational approach, detailing the overall level of advancement and some specific cases for reference. Great content explains the existing barriers in STEM education regarding gender, the remains to achieve greater access. Finally, the aspects that must be ensured were highlighted so that more women are an active part of STEM education and that this STEM education is an integral part of the knowledge and skills to develop entrepreneurial activities successfully.