Title
Modeling the Anomalous Flux of Proteins in the Human Kidney with the Diffusion Equation
Date Issued
20 February 2019
Access level
metadata only access
Resource Type
conference paper
Publisher(s)
Institute of Electrical and Electronics Engineers Inc.
Abstract
One of the first signals of the so-called diabetic nephropathy is attributed the anomalous flux of albumin through the zone of urine formation. This can be sustained on the hypothesis that the glucose's dipole moment would cancel the negative charges located over the inner layers of the renal glomerulus, leaving theses areas unprotected for stopping proteins and other charged compounds. In this paper, the diffusion's equation treated in cylinder coordinates is used to calculate the albumin excretion rate (AER) considering numerical inputs that feature those patients whose diagnosis of type-2 diabetes was done in more than 10 years. Our estimate is in agreement with the ones obtained with standard techniques commonly used in nephrology, with a 7% of error of model and numerical approximations.
Language
English
OCDE Knowledge area
Endocrinología, Metabolismo (incluyendo diabetes, hormonas)
Urología, Nefrología
Subjects
Scopus EID
2-s2.0-85063436628
ISBN of the container
9781538650325
Conference
2018 IEEE Biennial Congress of Argentina, ARGENCON 2018
Sources of information:
Directorio de Producción Científica
Scopus