Title
The Loxtox protein family in Loxosceles intermedia (Mello-Leitão) venom
Date Issued
01 December 2007
Access level
open access
Resource Type
journal article
Author(s)
Kalapothakis E.
Chatzaki M.
Gonçalves-Dornelas H.
de Castro C.S.
Silvestre F.G.
Laborne F.V.
de Moura J.F.
Veiga S.S.
Granier C.
Barbaro K.C.
Universidade Federal de Minas Gerais
Abstract
We isolated cDNA sequences coding for dermonecrotic/sphingomyelinases factor proteins from the brown spider Loxosceles intermedia, here named Loxtox proteins. The amino acid sequences based on cloned cDNA of several Loxtox proteins revealed at least six distinct groups of proteins expressed in the venom gland. The level of similarity among the toxins varied from 99% to 55%. The finding of several isoforms of Loxtox in the venom of this spider may reflect an evolutionary adaptation for different prey types and reinforces the idea of an efficient mutational mechanism in the venom gland of spiders. © 2007 Elsevier Ltd. All rights reserved.
Start page
938
End page
946
Volume
50
Issue
7
Language
English
OCDE Knowledge area
Toxicología
Subjects
Scopus EID
2-s2.0-35648952141
PubMed ID
Source
Toxicon
ISSN of the container
00410101
Sponsor(s)
Funding text
This research was supported by grants from FAPEMIG, CNPq, CAPES-COFECUB and PRONEX. E. Kalapothakis, K.C. Barbaro, C. Chávez-Olórtegui and S.S.Veiga are recipients of CNPq fellowships.
Sources of information:
Directorio de Producción Científica
Scopus