A new species of Chaetostoma was found in mountain tributaries of the río Marañon, Peru. The new species differs from all described congeners by having a tuft of odontodes, surrounded by naked skin, in the middle of each trunk lateral dermal plate, and in bearing more than 20 hypertrophied evertible odontodes on three cheek plates vs. evenly distributed odontodes on the whole surface of each dermal plate, and in bearing fewer than 20 hypertrophied evertible odontodes on three cheek plates in all other Chaetostoma species. The new species resembles two Cordylancistrus species in the presence of a tuft of odontodes in the middle of each trunk lateral dermal plate, but it exhibits a naked snout (vs. snout covered with plates in Cordylancistrus) and one uniquely derived character present in some species of Chaetostoma - a short, slender fourth branchiostegal ray.