This research work resulted in the development of novel inorganic nanocomposite hydrogels as an antibacterial agent. Novel inorganic hydrogels were developed from the Noveon AA-l Polycarbophil with acrylamide. Inorganic nanoparticles were produced by the nucleation of Ag and Au3 salts with extracts of mint leaf that formed within the hydrogels system. The characterizations of the hydrogels developed were done using, various electron microscopy such as scanning electron microscope with energy dispersive spectroscopy analysis and Transmission electron microscopy. Theses nanocomposite hydrogels were examined for their antibacterial activities against to E coli which indicate that these nanocomposite hydrogels can be used as possible candidates for advanced biomedical applications. © 2013 IEEE.