The present investigations are associated with designing Morlet wavelet neural network (MWNN) for solving a class of susceptible, infected, treatment and recovered (SITR) fractal systems of COVID-19 propagation and control. The structure of an error function is accessible using the SITR differential form and its initial conditions. The optimization is performed using the MWNN together with the global as well as local search heuristics of genetic algorithm (GA) and active-set algorithm (ASA), i.e., MWNN-GA-ASA. The detail of each class of the SITR nonlinear COVID-19 system is also discussed. The obtained outcomes of the SITR system are compared with the Runge-Kutta results to check the perfection of the designed method. The statistical analysis is performed using different measures for 30 independent runs as well as 15 variables to authenticate the consistency of the proposed method. The plots of the absolute error, convergence analysis, histogram, performance measures, and boxplots are also provided to find the exactness, dependability and stability of the MWNN-GA-ASA.