This study presents the characteristics of municipal solid waste (MSW) incineration ash obtained from an electric energy generation plant and evaluates the MSW ash applicability in base road pavement layers through the mixture of ash with a nonlateritic regional clay soil. Chemical, physical, and mechanical tests and the mechanistic-empirical design for a typical pavement structure were carried out on the pure soil and also in the soil mixture with the addition of different ash content (20 and 40%). Fly ash reduced the expansion of the material, showing an increase in the California bearing ratio (CBR) and resilient modulus value. The results are satisfactory, depending on the content and type of ash used, highlighting the positive work of MSW fly ash for its use in base road pavement layers. © 2014 American Society of Civil Engineers.