OBJECTIVE: To evaluate the association between the respiratory symptomatic status and sleep disturbance in Peru’s inhabitants over 15 years of age. MATERIAL AND METHOD: Secondary analysis of the Demographic and Family Health Survey (ENDES) 2015. A person with respiratory symptomatic status was one who reported having cough and phlegm for more than 14 days. A person with sleep disturbance was one who reported sleep disorders, fatigue and lack of concentration for more than 11 days in the last 14 days. The proposed association was evaluated using a generalized linear model. RESULTS: Data from 34,583 individuals were analyzed, evidencing a frequency of sleep disturbance and respiratory symptomatic status of 1.8% (590/33,478) and 2.8% (921/33,298), respectively. It was observed that participants with respiratory symptomatic status had sleep disturbances at a frequency of 1.54 times compared to those who did not have this characteristic, after adjusting for variables of interest. There was no significant difference in the frequency of sleep disturbances in relation to the duration of the respiratory symptomatic status (p = 0.992). CONCLUSIONS: There is enough evidence to suggest the possible relationship between the variables of interest, establishing that some or all the diseases associated with the respiratory symptomatic status are related to sleep disturbance.